Animal Disease Models (Microbiology)
The RVC provides services for testing efficacy of experimental vaccines and pharmaceuticals for prevention of farm animal disease.
Services
- Sourcing animals of known health status
- Efficacy testing of farm animal products using disease challenge models
- Preclinical safety testing of experimental farm animal products
- Sourcing new challenge isolates
- Exploratory studies to characterise the pathogenicity of new challenge isolates
- Study design advice
- Daily clinical assessments by experienced personnel
- In vivo sample collection
- Laboratory processing of samples and sample storage
- Full necropsy and gross assessment by trained veterinary surgeons
- Data management
- Statistical analyses and interpretation
Animal disease models recently used or conducted at RVC
(Reference papers available on request)
Cattle
- Bovine viral diarrhoea virus (Type I and Type II)
- Mannheimia haemolytica
Swine
- Mycoplasma hyopneumoniae
- Mycoplasma hyorhinis
- Actinobacillus pleuropneumoniae
- Sheehan, B.J., Bossé, J.T., Beddek, A.J. Rycroft, A.N., Kroll, J.S. & Langford, P.R. (2003). Identification of Actinobacillus pleuropneumoniae Genes important for survival during infection in its natural host. Infection & Immunity 71, 3960-3970.
- Rycroft, A.N., Pennings A. & van den Bosch, J. (1999). A. pleuropneumoniae subunit vaccine: compliance with European Pharmacopoeia efficacy testing in pigs. Proceedings of the 3rd International conference on Haemophilus, Actinobacillus & Pasteurella, August 1999.
- Porcine circovirus type 2 (PCV2)
- Mavrommatis, B., Offord, V., Patterson, R., Watson, M., Kanellos, T., Steinbach, F., Grierson, S. & Werling, D. (2014) Global gene expression profiling of myeloid immune cell subsets in response to in vitro challenge with porcine circovirus 2b. PLOS One, 9, 1-12
- Velasova, M., Alarcon P., Werling, D., Nevel A. & Wieland, B. (2013) Effectiveness of porcine circovirus type 2 vaccination in reducing the severity of post-weaning multisystemic wasting syndrome in pigs. The Veterinary Journal 197, 842-847
Standards
- GCP
- Quality Assurance services
- Standard Operating Procedures
Contact us
For further information, or to request a quote, please contact:
- email: business@rvc.ac.uk