The role of Sulf1 and Sulf2 variants in the regulation of normal development and its relevance to unregulated tumour growth: Recently discovered extracellular Sulfatases, Sulf1 and Sulf2, regulate the activities of multiple growth factors and signalling molecules. We are characterising further variants of these enzymes and the mechanisms of their differential actions in the regulation of normal cell growth of musculoskeletal elements including neuronal and endothelial cells. The irregularities in the regulation of these enzyme variants is being investigated in tumour tissues though their direct effect on tumour cell and indirect effect through angiogenesis.