Dr Edd Knowles
Post-doctoral Researcher in Neuromuscular Disease
Department: Clinical Science and Services
Research Groups: Musculoskeletal Biology
Clinical Groups: Equine Medicine
Edd is a post-doctoral researcher in neuromuscular disease, currently studying Atypical Myopathy in horses.
Edd graduated in 2005. After 18 months in small animal practice, moved to an equine private practice as a hosptial intern. He has remained in equine private practice whilst undertaking specialist training, a PhD and now post-doctoral research at the RVC. Edd obtained the diploma of the European College of Equine Internal Medicine in 2014 and is an RCVS recognised specialist in Equine Internal Medicine. Edd has broad research interests. He completed his PhD in 2021 focussed on equine endocrine disease and the prediction of laminitis. His post doctoral research focus is on Atypical Myopathy (hypoglycin A toxicity) in horses.
First Author Journal publications
Knowles EJ, Hyde C, Harris PA, Elliott J, Menzies-Gow NJ. Short Communication: Identification of equine corticotropin-like intermediate lobe peptide (CLIP) binding to an adrenocortipcotrophic hormone (ACTH) assay capture antibody. Domest Anim Endocrinol. 2023. online ahead of print doi: 10.1016/j.domaniend.2023.106785
Knowles, E.J., Elliott, J., Harris, P.A., Chang, Y.M. and Menzies-Gow, N.J., 2022 Predictors of laminitis development in a cohort of nonlaminitic ponies. Equine Vet. J. online ahead of print https://doi.org/10.1111/evj.13572
Knowles, E.J., Grieve, L., 2020. Clinical insights: Equine obesity. Equine Vet. J. 52, 635–638.
Knowles, E J, 2018. What is the risk that corticosteroid treatment will cause laminitis?? Equine Vet. Educ. 31,393-448
Knowles, E.J., 2018. Does pergolide therapy prevent laminitis in horses diagnosed with pituitary pars intermedia dysfunction? Equine Vet. Educ. 31, 278-280
Knowles, E.J., Shaw, S., Harris, P.A., Elliott, J., 2018. Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross-reactivity or interference. Equine Vet J 50, 672–677.
Knowles, E. J., Harris, P.A., Elliott, J., Menzies-Gow, N.J., 2017. Use of the oral sugar test in ponies when performed with or without prior fasting. Equine Vet. J. 49, 519-524
Knowles, E.J., Tremaine, W.H., Pearson, G.R., Mair, T.S., 2016. A database survey of equine tumours in the United Kingdom. Equine Vet. J. 48, 280-4
Knowles, E.J., Menzies-Gow, N.J., Mair, T.S., 2014. Plasma fructosamine concentrations in horses with pituitary pars intermedia dysfunction with and without laminitis. Equine Vet. J. 46, 249–51.
Knowles, E.J., Withers, J.M., Mair, T.S., 2012. Increased plasma fructosamine concentrations in laminitic horses. Equine Vet. J. 44, 226–9.
Knowles, E.J., Mair, T.S., Butcher, N., Waller, A.S., Wood, J.L.N., 2010. Use of a novel serological test for exposure to Streptococcus equi subspecies equi in hospitalised horses. Vet. Rec. 166, 294-7
Knowles, E.J. Mair, T.S. 2009 Colonic volvulus with defects of the mesenteric attachments in a yearling Friesian colt. Equine Vet. Educ. 21, 396-400
Knowles, E.J., Withers, J.M., Day, M.J., Mair, T.S., 2008. Renal carcinoma as a cause of sudden death in an aged horse. Equine Vet. Educ. 20, 452-5
Co-author Journal Publications
Dunkel B,?Knowles E.J., Chang Y.M., Menzies-Gow N.J. Vet 2021. Influence of endocrine disease on l-lactate concentrations in blood of ponies. J. Vet. Intern. Med. 35, 1582-1588
De Cozar, M., Sherlock, C., Knowles, E., Mair, T., 2020. Serum amyloid A and plasma fibrinogen concentrations in horses following emergency exploratory celiotomy. Equine Vet. J. 52, 59-66
Lawson, A.L., Opie, R.R., Stevens, K.B., Knowles, E.J., Mair, T.S., 2020. Application of an equine composite pain scale and its association with plasma adrenocorticotropic hormone concentrations and serum cortisol concentrations in horses with colic. Equine Vet. Educ. 32, 20-27
Mcgilvray, T.A., Knowles, E.J., Menzies-Gow, N.J., Harris, P.A., 2020. Comparison of immunofluorescence and chemiluminescence assays for measuring ACTH in equine plasma. Equine Vet. J. 52, 709-714
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., Atwood, R.C., Rutland, C.S., Menzies-Gow, N., Knowles, E., Elliott, J., Harris, P., Rauch, C., 2019. Physics of animal health: On the mechano-biology of hoof growth and form. J. R. Soc. Interface 16, 20190214
Dunkel, B., Knowles, E.J., Chang, Y.-M., Menzies-Gow, N.J., 2019. Correlation between l-lactate and glucose concentrations and body condition score in healthy horses and ponies. J. Vet. Intern. Med. 33, 2267-2271
Menzies-Gow, N.J., Knowles, E.J., Rogers, I., Rendle, D.I., 2019. Validity and application of immunoturbidimetric and enzyme-linked immunosorbent assays for the measurement of adiponectin concentration in ponies. Equine Vet. J. 51, 33-7
Rendle, D.I., McGregor Argo, C., Bowen, M., Carslake, H., German, A., Harris, P., Knowles, E., Menzies-Gow, N., Morgan, R., 2018. Equine obesity: current perspectives. UK-Vet Equine 2, 1–19.
Dunkel, B., Ryan, A., Haggett, E., Knowles, E.J., 2018. Atypical myopathy in the South-East of England: Clinicopathological data and outcome in hospitalised horses. Equine Vet. Educ. 32, 90-95
Smith, S., Naylor, R.J., Knowles, E.J., Mair, T.S., Cahalan, S.D., Fews, D., Dunkel, B., 2015. Suspected acorn toxicity in nine horses. Equine Vet. J. 47, 568-72
Van Heesewijk, N., Knowles, E.J., Palgrave, C.J., Mair, T.S., 2015. Treatment of a pulmonary granular cell tumour by repeated transendoscopic diode laser photoablation. Equine Vet. Educ. 27, 302-305
Naylor, R.J., Taylor, A.H., Knowles, E.J., Wilford, S., Linnenkohl, W., Mair, T.S., Johns, I.C., 2014. Comparison of flunixin meglumine and meloxicam for post-operative management of horses with strangulating small intestinal lesions. Equine Vet. J. 46, 427-34
Bird, A.R., Knowles, E.J., Sherlock, C.E., Pearson, G.R., Mair, T.S., 2012. The clinical and pathological features of gastric impaction in twelve horses. Equine Vet. J. Suppl. 44, 105-10
Da Rocha, S.T., Tevendale,M., Knowles, E, Takada,S.,Watkins,M., Ferguson-Smith, A.C. 2007. Restricted co-expression of Dlk-1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control. Dev.Biol. 306, 810-23