Dr Daniel Goldhill
PhD
Lecturer in Virology
Department: Pathobiology & Population Sciences
Campus: Hawkshead
Research Groups: Host-Pathogen Interactions and Vaccinology
I am a lecturer in virology. I am interested in how viruses evolve to jump between hosts or become resistant to antiviral drugs. I work with influenza viruses and canine coronaviruses. I am always interested to hear from students at the RVC or elsewhere who would like to join the lab.
Daniel is an evolutionary virologist who uses experimental evolution to study how viruses adapt. He did his undergraduate degree in Biological Sciences at Oxford before moving to Yale University to study bacteriophage evolution with Prof. Paul Turner for his PhD. He returned to the UK to study drug resistance to novel antivirals in influenza jointly between PHE and Imperial in Prof. Wendy Barclay’s lab. During 2020, he worked on understanding how mutations in the furin-cleavage site affect transmission in SARS-CoV-2. Recently, he has been studying how influenza evolves to overcome a host factor in chickens gene-edited to be resistant to influenza. He is currently using experimental evolution to research drug resistance in coronaviruses as well as investigting host switching in influenza.
Selected Papers:
6. Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Idoko-Akoh A, Goldhill DH, Sheppard CM, Bialy D, Quantrill JL, Sukhova K, et al. Nature Communications. 2023;14(1):6136.
5. An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization. Sheppard CM*, Goldhill DH*, Swann OC, Staller E, Penn R, Platt OK, et al. Nature Communications. 2023;14(1):6135.
4. Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Zhou J*, Peacock TP*, Brown JC*, Goldhill DH*... et al. 2022. Cell Reports.
3. 2020 Hindsight: Should evolutionary virologists have expected the unexpected during a pandemic? Goldhill DH, Barclay WS. 2021. Evolution.
2. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets. Peacock TP*, Goldhill DH*, Zhou J*, Baillon L*, Frise R*, Swann OC, Kugathasan R, Penn R, Brown JC, Sanchez-David RY, Braga L, Williamson MK, Hassard JA, Staller E, Hanley B, Osborn M, Giacca M, Davidson AD, Matthews DA, Barclay WS. 2021. Nat Microbiol 6:899-909.
1. The mechanism of resistance to favipiravir in influenza. Goldhill DH, Te Velthuis AJ, Fletcher RA, Langat P, Zambon M, Lackenby A, Barclay WS. 2018. Proceedings of the National Academy of Sciences 115:11613-11618.
I teach virology to vets, bioscience undergraduates and postgraduate students. I am happy to host RP2 and student projects either based in the lab or purely computational projects.
Skype-a-Scientist.
Please send me an email if you are interested in having me talk to your school/group about viruses or studying biology at university.
For media requests, please email me at dgoldhill@rvc.ac.uk or jasmin.devivo@plmr.co.uk.